| Idea Name: |
GBM |
| Slogan: |
Gut microbiome and GBM |
| Supervisor Name: |
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| Supervisor School: |
ASAB |
| Supervisor Department: |
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| Contact number: |
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| Abstract: |
| Gut microbiota and brain are directly linked via gut brain axis. Metabolites of gut microbiota during GBM play role in immune suppression and GBM progression. |
| What is the unmet need in society that your idea will fulfill ? |
| By this method, we can diagnose GBM non-invasively. By changing the composition of certain gut microbiota whose metabolites can decrease GBM progression can serve as a potential therapy. |
| Who needs it ? How many would benefit ? |
| Patients suffering from Glioblastoma Multiforme need it. Because this will help to understand the link between Gut microbiota, immune system and brain. By characterization of these metabolites secreted by gut microbiota specifically in GBM, we can determine their role in disease progression. |
| How will the solution works |
| Collection of stool samples from GBM patients and healthy controls. Isolation of microbial cells from them by differential centrifugation. Extraction and characterization of these metabolites by proteomic techniques. Compare these with each other in both normal and disease condition. Select those which are present only in GBM condition. Determine their role in GBM progression by injecting them into mice or by altering the gut microbiota in mice which will produce these metabolites. |
| Who are your competitors ? How is your solution different |
| There is research going on various biomarkers associated with GBM. These specific gut microbiota and their specific metabolites in these GBM condition can also serve as useful biomarkers. But they can be used to diagnose GBM noninvasively. |
| Status: |
new |
| Entry Date & Time: |
2021-01-10 (0750) |
