| Idea Name: |
Bilayer Tablet |
| Slogan: |
Approved combination not available worldwide |
| Supervisor Name: |
Dr. Muhammad Zaman |
| Supervisor Designation: |
Associate Professor |
| Supervisor School: |
Other |
| Supervisor Department: |
Department of Pharmacy |
| Contact number: |
03336823913 |
| Email ID: |
[email protected] |
| Abstract: |
| An orally administered bilayer tablet with Tamsulosin as sustained release and Finasteride as immediate release was manufactured for patient compliance and cost effectiveness as majority population using this combination are geriatrics. Tablets were prepared by direct compression with outer layer coating and evaluated. Results of evaluations were found within acceptable range. |
| What is the unmet need in society that your idea will fulfill ? |
| The combination therapy was found beneficial for treatment of benign prostatic hyperplasia as compared to monotherapy and individual products are available of each active ingredient thus making it costly and reducing patient compliance. |
| Who needs it ? How many would benefit ? |
| Men with BPH as its prevalent in almost 50% male population above 50 years. |
| How will the solution works |
| A response surface methodology was employed in formulating bilayer tablet with individual release layer i.e sustain release layer and Immediate release layer. Independent variables selected in both cases comprise of Hydroxy propyl methylcellulose as sustained release polymer, and avicel PH102 in inner core while Triacetin and talc in outer layer respectively. Assay method on HPLC was developed and validated for simultaneous determination of both actives, dissolution test also found satisfactory |
| Who are your competitors ? How is your solution different |
| There are no competitors as this combination isn't available in a single dosage form but this combination therapy is approved by regulated authorities. |
| Status: |
new |
| Entry Date & Time: |
2022-12-31 (0707) |
